Lovely article. I went through this cycle two times now and I'm only 38...first my science career - I didn't want to be "successful" anymore and was craving peace, a simple life and deep meaningful relationships. Then in my last job at a Startup - I quickly moved up in positions, until I had so much responsibility again that I couldn't even go on a long weekend hike. Mind you, I wasn't "super successful" like the people you mentioned in your article. But I was earning more than double the amount I needed to live. And the more "successful" I became in both of those careers, the more unhappy I became.